%0 Journal Article
%A Tlatelpa Romero, Beatriz
%A Vázquez de Lara Cisneros, Luis G.
%A Cañadas Benito, Olga
%A Blanco Rivero, Amaya
%A Olmeda Lozano, Bárbara
%A Pérez Gil, Jesús
%A Mendoza Milla, Criselda
%A Martinez Vaquero, José Luis
%A Romero, Yair
%A Contreras Cruz, David Atahualpa
%A de la Rosa Paredes, René
%A Ruiz Salgado, Sinuhé
%A Berra Romani, Roberto
%A Collantes Gutiérrez, Alonso Antonio
%A Pérez Fernández, María Susana
%A Hernández Linares, María Guadalupe
%A Guerrero Luna, Gabriel
%T Modulation of pulmonary fibrosis by pulmonary surfactant-associated phosphatidylethanolamine in vitro and in vivo
%D 2025
%@ 1661-6596
%U https://hdl.handle.net/20.500.14352/124300
%X Pulmonary fibrosis (PF) is characterized by excessive collagen deposition and impaired lung function. Pulmonary surfactant may modulate fibroblast activity and offer therapeutic benefits. We developed a natural porcine pulmonary surfactant (NPPS) enriched with 1,2-dipalmitoyl-rac-glycero-3-phosphatidylethanolamine (PE) and evaluated its biophysical and biological properties. Biophysical analysis showed that PE improved surfactant performance by increasing surface pressure and stability. In vitro, NPPS-PE reduced collagen expression and induced apoptosis in normal human lung fibroblasts; in addition, it decreased proliferation in fibroblasts stimulated with TGF-β. In vivo, NPPS-PE improved gas exchange and significantly reduced collagen deposition in bleomycin-treated mice. These findings suggest that NPPS-PE may be a promising therapeutic strategy for fibrosing lung diseases.
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