RT Journal Article
T1 High Frequency of Detection of NDM-ProducingEnterobacterales Among Companion Animals Hospitalized in anItalian Veterinary Teaching Hospital
A1 Scarpellini, R.
A1 Pulido Vadillo, M.
A1 Serna Bernaldo, Carlos
A1 González Zorn, Bruno
A1 Blanco, J. L.
A1 Delgado Blas, J. F.
A1 Giunti, M.
A1 Piva, S.
AB Carbapenems are considered one of the most important last-resort classes of antibiotics, and the spread of carbapenem-resistant Enterobacterales (CRE) is a serious concern worldwide. From a One Health point of view, reports on CRE in companion animals are increasing, requiring attention regarding their role in maintenance and direct transmission to humans. The aim of this study was to assess the frequency of detection at admission and the in-hospital acquisition of CRE from perirectal swabs in dogs and cats hospitalized in an Italian Veterinary Teaching Hospital (VTH). Of the 150 patients sampled, 11.3% (n = 17) were CRE carriers at admission, 25.6% (n = 34) acquired CRE in their commensal microbiota during their hospital stay, and 2% (n = 3) developed an infection caused by CRE. Genotypical analysis showed that in 100% (78/78) of the CRE isolates (44 Escherichia coli, 33 Klebsiella pneumoniae, and 1 Klebsiella aerogenes) carbapenem resistance was conferred by the carbapenemase gene blaNDM, suggesting an endemic presence of such gene within the hospital. Co-occurrent β-lactamase-encoding genes were found in most of the isolates. Risk factors associated with CRE acquisition were length of hospitalization (p = 0.0002) and treatment with piperacillin–tazobactam (PTZ; p = 0.0380), indicating potential cross-selection of CRE. These results reinforce the suspicion that companion animals could silently contribute to the maintenance and dissemination of CRE in the local community, posing a threat to global health
PB Wiley
SN 1865-1674
YR 2025
FD 2025-01-09
LK https://hdl.handle.net/20.500.14352/115226
UL https://hdl.handle.net/20.500.14352/115226
LA eng
NO Scarpellini, R., Pulido-Vadillo, M., Serna, C., Gonzalez-Zorn, B., Blanco, J. L., Delgado-Blas, J. F., Giunti, M., Piva, S., High Frequency of Detection of NDM-Producing Enterobacterales Among Companion Animals Hospitalized in an Italian Veterinary Teaching Hospital, Transboundary and Emerging Diseases, 2025, 2622185, 9 pages, 2025. https://doi.org/10.1155/tbed/2622185
DS Docta Complutense
RD 20 abr 2025