RT Journal Article
T1 Study of the impact of the vascular systemic risk factors on peripapillary vascular density by optical coherence tomography angiography
A1 Tolosa Tort, Cristina
A1 Poza Martín, Emma
A1 García Feijoo, Julián
A1 Méndez Hernández, Carmen Dora
AB BackgroundThe focus of therapeutic tools in glaucoma has been mainly to control of intraocular pressure. Recently there has been a growing interest in investigating the relationship of vascular risk factors in the development of glaucoma. The aim of this study was to assess the association between systemic arterial hypertension, diabetes mellitus and hypercholesterolemia, and peripapillary vascularization measured by Optical Coherence Tomography Angiography (OCTA) in glaucoma and healthy subjects.MethodsIn this unicenter, observational, cross-sectional study, 212 subjects, 118 glaucoma patients and 94 controls were consecutively recruited. Of these, 86 participants were excluded due to poor OCTA image quality. Therefore, 146 subjects were included in the final analysis, 74 glaucoma patients and 72 controls.Using a linear regression model, with 95% confidence and 80% statistical power, the effect of vascular risk factors on OCTA parameters in the 146 subjects included in the final analysis was studied.ResultsNo significant impact of vascular risk factors on OCTA measurements was found. Diabetic patients tended to show a lower peripapillary perfusion vascular density than subjects without diabetes (β 0.016, 95%CI 0.003;0.030, p 0.016). Similarly, hypercholesterolemia patients appeared to show less peripapillary flow index than non-hypercholesterolaemic patients (β 0.029, 95%CI 0.013;0.046, p 0.001). Glaucoma patients had 0.02% lower peripapillary perfusion vascular density (β 0.020, 95% CI 0.011;0.029, p < 0.001), 0.04% lower peripapillary flow index (β 0.036, 95%CI 0.022;0.051, p < 0.001) and 9.62% thinner retinal nerve fibre layer (β 9.619, 95%CI 5.495;13.744, p < 0.001).ConclusionsIn conclusion glaucoma has greater effect on peripapillary vascular density parameters than any of the vascular risk factors analyzed.
PB Springer Nature
SN 0721-832X
YR 2024
FD 2024-07-11
LK https://hdl.handle.net/20.500.14352/119545
UL https://hdl.handle.net/20.500.14352/119545
LA eng
NO Tolosa-Tort, C., Poza-Martin, E., Garcia-Feijoo, J. et al. Study of the impact of the vascular systemic risk factors on peripapillary vascular density by optical coherence tomography angiography. Graefes Arch Clin Exp Ophthalmol 262, 3933–3946 (2024). https://doi.org/10.1007/s00417-024-06576-w
DS Docta Complutense
RD 25 feb 2026