RT Journal Article T1 Se and Hg in processed fish-derived products and their fish raw materials: occurrence, Se:Hg molar ratio, HBVSe index, bioaccessibility and caco-2 cells toxicity A1 Fernández Bautista, Tamara A1 Gómez Gómez, Beatriz A1 Gracia Lor, Emma A1 Pérez Corona, María Teresa A1 Madrid, Yolanda AB Processing conditions applied during food production could affect food component contents and bioaccessibility. Here, possible changes in Hg and Se total and species contents and bioaccessibility have been tracked in each stage of the production chain of processed fish-derived products. Therefore, Se:Hg molar ratio and Selenium Health Benefit Value (HBVSe) were calculated for final products and raw materials, resulting favorable in all cases, suggesting the safety of surimi-based products regarding mercury. Speciation studies revealed the presence of SeMeSeCys and SeMet in all samples. Thus, the integrity of the selenium species seems to be maintained. Moreover, in vitro gastrointestinal digestion model evidenced that Se bioaccessibility ranged between 20–39 % for all samples, while in case of Hg was between 8–37 %. Additionaly, SeMeSeCys and SeMet were also identified in the gastrointestinal extracts. Finally, no cytotoxicity was observed after exposure of Caco-2 cells to the gastrointestinal extracts. PB Elsevier SN 0963-9969 YR 2024 FD 2024-07-29 LK https://hdl.handle.net/20.500.14352/112327 UL https://hdl.handle.net/20.500.14352/112327 LA eng NO Tamara Fernández-Bautista, Beatriz Gómez-Gómez, Emma Gracia-Lor, Teresa Pérez-Corona, Yolanda Madrid, Se and Hg in processed fish-derived products and their fish raw materials: Occurrence, Se:Hg molar ratio, HBVSe index, bioaccessibility and Caco-2 cells toxicity, Food Research International, Volume 192, 2024, 114851, ISSN 0963-9969, https://doi.org/10.1016/j.foodres.2024.114851. (https://www.sciencedirect.com/science/article/pii/S0963996924009219) NO Comunidad de Madrid NO Universidad Complutense de Madrid DS Docta Complutense RD 21 abr 2025