%0 Journal Article
%A López Peña, Gabriel
%A Hamraoui, Khouloud
%A Horchan Naifer, Karima
%A Gerke, Christoph
%A Ortgies, Dirk H.
%A Martín Rodríguez, Emma
%A Chen, Guanying
%A Jaque García, Daniel
%A Rubio Retama, Benito Jorge
%T Lanthanide doped nanoheaters with reliable and absolute temperature feedback
%D 2022
%@ 09214526
%U https://hdl.handle.net/20.500.14352/71387
%X The development of selective and controlled photo-thermal therapies requires luminescent nanoparticles capable of simultaneous heating and contactless thermal sensing. Until now, thermal therapies have suffered from a lack of control over the absolute temperature of the treated tissue because the nanothermometers used for thermal feedback, based on a spectral analysis of emitted radiation, were affected by the inhomogeneous extinction of the tissues. This work shows how this deficiency can be overcome by using core-shell-shell nanostructures doped with lanthanide ions (Nd3+ and Yb3+). Thermal reading was achieved from the analysis of the Yb3+ luminescence lifetime whereas simultaneous heating was achieved thanks to the non-radiative deexcitations of Nd3+ ions. Simple proof-of-concept experiments show the great potential of these lanthanide-doped nanostructures for the development of in vivo photo-thermal treatments with absolute and reliable thermal feedback.
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