RT Journal Article
T1 Lanthanide doped nanoheaters with reliable and absolute temperature feedback
A1 López Peña, Gabriel
A1 Hamraoui, Khouloud
A1 Horchan -Naifer, Karima
A1 Gerke, Christoph
A1 Ortgies, Dirk H.
A1 Martín Rodríguez, Emma
A1 Chen, Guanying
A1 Jaque García, Daniel
A1 Rubio Retama, Jorge
AB The development of selective and controlled photo-thermal therapies requires luminescent nanoparticles capable of simultaneous heating and contactless thermal sensing. Until now, thermal therapies have suffered from a lack of control over the absolute temperature of the treated tissue because the nanothermometers used for thermal feedback, based on a spectral analysis of emitted radiation, were affected by the inhomogeneous extinction of the tissues. This work shows how this deficiency can be overcome by using core-shell-shell nanostructures doped with lanthanide ions (Nd3+ and Yb3+). Thermal reading was achieved from the analysis of the Yb3+ luminescence lifetime whereas simultaneous heating was achieved thanks to the non-radiative deexcitations of Nd3+ ions. Simple proof-of-concept experiments show the great potential of these lanthanide-doped nanostructures for the development of in vivo photo-thermal treatments with absolute and reliable thermal feedback.
PB Elsevier
SN 09214526
YR 2022
FD 2022-01-18
LK https://hdl.handle.net/20.500.14352/71387
UL https://hdl.handle.net/20.500.14352/71387
LA eng
NO Ministerio de Ciencia e Innovación (MICINN)
DS Docta Complutense
RD 17 ago 2024