RT Journal Article
T1 Beneficial Effect of Bariatric Surgery on Abnormal MMP-9 and AMPK Activities: Potential Markers of Obesity-Related CV Risk
A1 García Prieto, Concepcion
A1 Gil Ortega, Marta
A1 Vega Martín, Elena
A1 Ramiro Cortijo, David
A1 Martín Ramose, Mirian
A1 Bordiú Obonza, María Elena
A1 Sánchez Pernaute, Andrés
A1 Torres García, Antonio José
A1 Aranguez, I
A1 Fernández Alfonso, María Soledad
A1 Rubio Herrera, Miguel Ángel
A1 Somoza, Beatriz
AB Bariatric surgery (BS) results in sustained weight loss and may reverse inflammation, metabolic alterations, extracellular matrix remodeling and arterial stiffness. We hypothesize that increased stiffening in omental arteries from obese patients might be associated with an increase in MMP activity and a decrease in p-AMPK, together with systemic oxidative stress and inflammation. Moreover, BS could contribute to reversing these alterations. This study was conducted with 38 patients of Caucasian origin: 31 adult patients with morbid obesity (9 men and 22 women; mean age 46 years and BMI = 42.7 +/- 1.0 kg/m(2)) and 7 non-obese subjects (7 women; mean age 45 years and BMI = 22.7 +/- 0.6 kg/m(2)). Seventeen obese patients were studied before and 12 months after BS. The stiffness index beta, an index of intrinsic arterial stiffness, was determined in omental arteries and was significantly higher in obese patients. Levels of phosphorylated AMPK (p-AMPK(Thr-172)) and SIRT-1 were significantly lower in peripheral blood mononuclear cells (PBMCs) from obese patients than those from non-obese patients (p < 0.05) and were normalized after BS. Total and active MMP-9 activities, LDH, protein carbonyls and uric acid were higher in obese patients and reduced by BS. Moreover, there was a correlation between plasmatic LDH levels and the stiffness index beta. BS has a beneficial effect on abnormal MMP-9, LDH and AMPK activities that might be associated with the development of arterial stiffness in obese patients. Since these parameters are easily measured in blood samples, they could constitute potential biomarkers of cardiovascular risk in morbid obesity.
PB Frontiers media
SN 1664-042X
YR 2019
FD 2019
LK https://hdl.handle.net/20.500.14352/129538
UL https://hdl.handle.net/20.500.14352/129538
LA eng
NO García-Prieto CF, Gil-Ortega M, Vega-Martín E, Ramiro-Cortijo D, Martín-Ramos M, Bordiú E, Sanchez-Pernaute A, Torres A, Aránguez I, Fernández-Alfonso M, Rubio MA and Somoza B (2019) Beneficial Effect of Bariatric Surgery on Abnormal MMP-9 and AMPK Activities: Potential Markers of Obesity-Related CV Risk. Front. Physiol. 10:553. doi: 10.3389/fphys.2019.00553
NO Fundación Mutua Madrileña (España)
NO Sociedad Española de Metabolómica
NO Fundación Universitaria San Pablo-CEU (España)
DS Docta Complutense
RD 19 may 2026