TY  - JOUR
AU  - Hernández Jiménez, Macarena
AU  - Martín-Vílchez, Samuel
AU  - Ochoa, Dolores
AU  - Mejía-Abril, Gina
AU  - Román, Manuel
AU  - Camargo-Mamani, Paola
AU  - Luquero-Bueno,  Sergio
AU  - Jilma, Bernd
AU  - Moro Sánchez, María Ángeles
AU  - Fernández Gómez-Chacón, Gerónimo Félix
AU  - Piñeiro,  David
AU  - Ribó, Marc
AU  - González,  Víctor M
AU  - Lizasoaín Hernández, Ignacio
AU  - Abad-Santos,  Francisco
PY  - 2022
UR  - https://hdl.handle.net/20.500.14352/113553
T2  - Mol Ther Nucleic Acids
AB  - ApTOLL is an aptamer that antagonizes Toll-like receptor 4 and improves functional outcomes in models of ischemic stroke and myocardial infarction. The aim of this study was to characterize the safety and pharmacokinetics of ApTOLL in healthy...
LA  - eng
M2  - 124
PB  - Cell Press
KW  - MT: oligonucleotides
KW  - MT: therapies and applications
KW  - TLR4
KW  - Antagonist
KW  - Aptamer
KW  - Clinical trial
KW  - First-in-human
KW  - Healthy subjects
KW  - Inflammation
KW  - Pharmacokinetics
KW  - Safety
TI  - First-in-human phase I clinical trial of a TLR4-binding DNA aptamer, ApTOLL: Safety and pharmacokinetics in healthy volunteers
TY  - journal article
VL  - 28
ER  -