%0 Journal Article
%A Ruiz Serrano, Miriam
%A López-Alvarado Gutiérrez, María Pilar
%A Menéndez Ramos, José Carlos
%T Concise and very efficient synthesis of the N-methylwelwistatin tetracyclic core based on an anionic domino process
%D 2010
%@ 1477-0520
%U https://hdl.handle.net/20.500.14352/128965
%X An efficient synthesis of the N-methylwelwistatin tetracyclic core in only two steps from Kornfeld's ketone is described, whose key transformation involves the generation of a fused bicyclo[4.3.1]decane ring system through a one-pot sequence comprising a Michael-intramolecular aldolization anionic domino process and a DBU-promoted hydrolysis of the N-pivaloyl protecting group. Besides providing the most efficient synthesis of the welwistatin core to date, this method has the advantage of installing an oxygenated function at the welwistatin D ring.
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