RT Journal Article
T1 Concise and very efficient synthesis of the N-methylwelwistatin tetracyclic core based on an anionic domino process
A1 Ruiz Serrano, Miriam
A1 López-Alvarado Gutiérrez, María Pilar
A1 Menéndez Ramos, José Carlos
AB An efficient synthesis of the N-methylwelwistatin tetracyclic core in only two steps from Kornfeld's ketone is described, whose key transformation involves the generation of a fused bicyclo[4.3.1]decane ring system through a one-pot sequence comprising a Michael-intramolecular aldolization anionic domino process and a DBU-promoted hydrolysis of the N-pivaloyl protecting group. Besides providing the most efficient synthesis of the welwistatin core to date, this method has the advantage of installing an oxygenated function at the welwistatin D ring.
PB Royal Society of Chemistry
SN 1477-0520
YR 2010
FD 2010
LK https://hdl.handle.net/20.500.14352/128965
UL https://hdl.handle.net/20.500.14352/128965
LA eng
NO Ruiz M, López-Alvarado P, Menéndez JC. Concise and very efficient synthesis of the N-methylwelwistatin tetracyclic core based on an anionic domino process. Org Biomol Chem. 2010 Oct 21;8(20):4521-3. doi: 10.1039/c0ob00382d. Epub 2010 Aug 18. PMID: 20717611.
NO Received 5th July 2010, Accepted 3rd August 2010
DS Docta Complutense
RD 31 dic 2025