RT Journal Article
T1 Blocking Estrogen Synthesis Leads to Different Hormonal Responses in Canine and Human Triple Negative Inflammatory Breast Cancer
A1 Cáceres Ramos, Sara Cristina
A1 Monsalve, Beatriz
A1 Alonso-Diez, Angela
A1 Crespo, Belén
A1 Illera del Portal, Josefina María
A1 Andrés Gamazo, Paloma Jimena de
A1 Silván Granado, Gema
A1 Illera Del Portal, Juan Carlos
AB Blocking estrogen synthesis by inhibitors of estrogen synthesis is a widely used therapy against estrogen receptor-positive tumors. However, these therapies are less effective in negative expression tumors. Therefore, this study determined the effectiveness of anti-aromatase and anti-sulfatase therapies in canine and human inflammatory breast cancer. Cell cultures and xenografts from IPC-366 and SUM149 were treated with different doses of letrozole (anti-aromatase) and STX-64 (anti-sulfatase), in order to observe their effectiveness in terms of cell proliferation, tumor progression, and the appearance of metastases and hormonal profiles. The results revealed that both treatments are effective in vitro since they reduce cell proliferation and decrease the secreted estrogen levels. In xenograft mice, while treatment with letrozole reduces tumor progression by 30-40%, STX-64 increases tumor progression by 20%. The hormonal results obtained determined that STX-64 produced an increase in circulating and intratumoral levels of estradiol, which led to an increase in tumor progression. However, letrozole was able to block estrogen synthesis by decreasing the levels of circulating and intratumoral estrogen and thus slowing down tumor progression. In conclusion, letrozole can be an effective treatment for canine and human inflammatory breast cancer. The knowledge of the hormonal profile of breast tumors reflects useful information on the effectiveness of different endocrine treatments.
PB MDPI
SN 2072-6694
YR 2021
FD 2021
LK https://hdl.handle.net/20.500.14352/94904
UL https://hdl.handle.net/20.500.14352/94904
LA eng
NO Caceres S, Monsalve B, Alonso-Diez A, Crespo B, Illera MJ, de Andres PJ, Silvan G, Illera JC. Blocking Estrogen Synthesis Leads to Different Hormonal Responses in Canine and Human Triple Negative Inflammatory Breast Cancer. Cancers (Basel). 2021 Oct 2;13(19):4967. doi: 10.3390/cancers13194967. PMID: 34638451; PMCID: PMC8507680.
NO Ministerio de Ciencias,  Innovación y Universidades (España)
NO Instituto de Salud Carlos III
DS Docta Complutense
RD 5 abr 2025