RT Journal Article
T1 Latent Microsporidia Infection Prevalence as a Risk Factor in Colon Cancer Patients
A1 Redondo Martínez, Fernando
A1 Hurtado-Marcos, Carolina
A1 Izquierdo Arias, Fernando
A1 Cuéllar Del Hoyo, María Del Carmen
A1 Fenoy Rodríguez, Soledad
A1 Sáez Álvarez, Yanira
A1 Magnet Dávila, Ángela
A1 Galindo-Regal, Lorena
A1 Uribe, Natalia
A1 López-Bañeres, Manuel
A1 Jiménez, Ana Isabel
A1 Llombart-Cussac, Antonio
A1 Águila De La Fuente, Carmen Del
A1 Andreu-Ballester, Juan Carlos
AB Microsporidia are opportunistic intracellular parasites, generating serious pathology in individuals with a compromised immune system. Infection by microsporidia inhibits p53 and Caspase 3, proteins involved in apoptosis and the cell cycle, which are vital in the malignant process of epithelial cells. The presence of microsporidia in the intestinal tissues of 87 colon cancer (CC) patients and 25 healthy controls was analyzed by real-time PCR and an immunofluorescence antibody test. Anti-Encephalitozoon antibodies were analyzed in serum samples by ELISA (enzyme linked immunosorbent assay). In 36 (41.3%) CC cases, microsporidia infections were identified in their tissues vs. no cases among control subjects (p &lt; 0.0001). An increase in IgG and IgE anti-Encephalitozoon antibodies was found in patients with CC, which would demonstrate continuous and previous contact with the parasite. The high prevalence of microsporidia in tissues and the seroprevalence in patients with CC suggest a relationship between microsporidia and the etiopathogenesis of CC.</jats:p>
PB MDPI
SN 2072-6694
YR 2022
FD 2022-10-29
LK https://hdl.handle.net/20.500.14352/101465
UL https://hdl.handle.net/20.500.14352/101465
LA eng
NO Redondo F, Hurtado-Marcos C, Izquierdo F, Cuéllar C, Fenoy S, Sáez Y, Magnet Á, Galindo-Regal L, Uribe N, López-Bañeres M, Jiménez AI, Llombart-Cussac A, Del Águila C, Andreu-Ballester JC. Latent Microsporidia Infection Prevalence as a Risk Factor in Colon Cancer Patients. Cancers (Basel). 2022 Oct 29;14(21):5342. doi: 10.3390/cancers14215342. PMID: 36358760; PMCID: PMC9658866.
NO Banco Santander Foundation-CEU Foundation
DS Docta Complutense
RD 4 ago 2024