RT Journal Article
T1 Comparing corneal variables in healthy subjects and patients with primary open-angle glaucoma
A1 Saenz Frances, F
A1 García Feijoo, Julián
A1 Jáñez Escalada, Luis
A1 Borrego Sanz, L
A1 Martínez De La Casa Fernández-Borrella, José María
A1 Fernández Vidal, Ana María
A1 Méndez Hernández, Carmen Dora
A1 Santos Bueso, Enrique Miguel
A1 Reche-Frutos, J
A1 García Sánchez, Julián
AB Purpose. This study was designed to identify possible differences between healthy subjects and patients with primary open-angle glaucoma (POAG) in keratometry, central corneal thickness, overall corneal thickness, mean thickness of a circular zone centered at the corneal apex of 1-mm radius (zone I), and mean thickness of several concentric rings also centered at the apex of 1-mm width (zones II to VI, respectively). Methods. These variables were recorded in 126 healthy subjects and 130 patients with POAG. Corneal thicknesses and the power of the flattest and steepest axes were compared between the two populations using a t-test and the position of the flattest axis using a Mann-Whitney U test. A binary logistic regression procedure was used to determine the diagnostic capacity of the corneal variables using the area under the receiver operator characteristic curve (AUC) to select the best regression equation. Results. Significant differences between subjects and patients were detected in mean corneal thickness and in mean thicknesses of zones I to VI. The logistic regression model included as predictors the mean corneal thickness and the mean thicknesses of zones IV and VI; for this model, the AUC was 0.711, sensitivity was 67.7%, and specificity was 65.5%. Conclusions. Healthy subjects and glaucoma patients differ significantly in terms of mean overall corneal thickness and thicknesses of the corneal zones I to VI defined here. The variables mean corneal thickness and mean thicknesses of zones IV and VI are able to discriminate between subjects with or without glaucoma. © 2011 The Association for Research in Vision and Ophthalmology, Inc.
PB The Association for Research in Vision and Ophthalmology
YR 2011
FD 2011-05
LK https://hdl.handle.net/20.500.14352/107384
UL https://hdl.handle.net/20.500.14352/107384
LA eng
NO Saenz-Frances F, Garcia-Feijó J, Jañez L, Borrego-Sanz L, Martinez de la Casa JM, Fernandez-Vidal A, Mendez-Hernández C, Santos-Bueso E, Reche-Frutos J, Garcia-Sánchez J. Comparing corneal variables in healthy subjects and patients with primary open-angle glaucoma. Invest Ophthalmol Vis Sci. 2011 Jun 1;52(6):3683-8. doi: 10.1167/iovs.10-6660. PMID: 21296827.
NO Instituto de Salud Carlos III
DS Docta Complutense
RD 21 abr 2025