RT Journal Article
T1 Dietary polyphenols in metabolic and neurodegenerative diseases: Molecular targets in autophagy and biological effects
A1 García Aguilar, Ana
A1 Palomino Ruiz-Poveda, Olga María
A1 Benito De Las Heras, Manuel R.
A1 Guillén Viejo, Carlos
AB Polyphenols represent a group of secondary metabolites of plants which have been analyzed as potent regulators of multiple biological processes, including cell proliferation, apoptosis, and autophagy, among others. These natural compounds exhibit beneficial effects and protection against inflammation, oxidative stress, and related injuries including metabolic diseases, such as cardiovascular damage, obesity and diabetes, and neurodegeneration. This review aims to summarize the mechanisms of action of polyphenols in relation to the activation of autophagy, stimulation of mitochondrial function and antioxidant defenses, attenuation of oxidative stress, and reduction in cell apoptosis, which may be responsible of the health promoting properties of these compounds.
PB MDPI
YR 2021
FD 2021
LK https://hdl.handle.net/20.500.14352/116426
UL https://hdl.handle.net/20.500.14352/116426
LA eng
NO García-Aguilar, A.; Palomino, O.; Benito, M.; Guillén, C. Dietary Polyphenols in Metabolic and Neurodegenerative Diseases: Molecular Targets in Autophagy and Biological Effects. Antioxidants 2021, 10, 142. https://doi.org/10.3390/antiox10020142
NO Ministerio de Ciencia e Innovación (España)
NO Instituto de salud Carlos III
DS Docta Complutense
RD 6 abr 2025