RT Journal Article
T1 The Factor H protein family: The switchers of the complement alternative pathway
A1 Lucientes Continente, Laura
A1 Márquez Tirado, Bárbara
A1 Goicoechea de Jorge, Elena
AB The factor H (FH) protein family is emerging as a complex network of proteins controlling the fate of the complement alternative pathway (AP) and dictating susceptibility to a wide range of diseases including infectious, inflammatory, autoimmune, and degenerative diseases and cancer. Composed, in man, of seven highly related proteins, FH, factor H-like 1, and 5 factor H-related proteins, some of the FH family proteins are devoted to down-regulating the AP, while others exert an opposite function by promoting AP activation. Recent findings have provided insights into the molecular mechanisms defining their biological roles and their pathogenicity, illustrating the relevance that the balance between the regulators and the activators within this protein family has in defining the outcome of complement activation on cell surfaces. In this review we will discuss the emerging roles of the factor H protein family, their impact in the complement cascade, and their involvement in the pathogenesis of complementmediated diseases associated with the AP dysregulation.
PB Wiley
SN 0105-2896
YR 2022
FD 2022-11-16
LK https://hdl.handle.net/20.500.14352/72698
UL https://hdl.handle.net/20.500.14352/72698
LA eng
NO CRUE-CSIC (Acuerdos Transformativos 2022)
NO Unión Europea. Horizonte 2020
NO Ministerio de Ciencia e Innovación (MICINN)
NO Instituto de Salud Carlos III (ISCIII)/FEDER
NO Comunidad de Madrid
DS Docta Complutense
RD 6 may 2024