RT Journal Article
T1 Candida albicans: A Comprehensive View of the Proteome
A1 Borrajo López, Ana
A1 Pitarch Velasco, Aída
A1 Molero Martín-Portugués, María Gloria
A1 Monteoliva Díaz, Lucía
A1 Gomez-Artiguez, Leticia
A1 Cámara-Fuentes de la, Samuel
A1 Sun, Zhi
A1 Hernáez, María Luisa
A1 Moritz, Robert L.
A1 Deutsch, Eric W.
A1 Gil, Concha
AB We describe a new release of the Candida albicansPeptideAtlas proteomics spectral resource (build 2024-03),providing a sequence coverage of 79.5% at the canonical proteinlevel, matched mass spectrometry spectra, and experimental evidence identifying 3382 and 536 phosphorylated serine and threonine sites with false localization rates of 1% and 5.3%, respectively. We provide a tutorial on how to use the PeptideAtlas and associated tools to access this information. The C. albicans PeptideAtlas summary web page provides “Build overview”, “PTM coverage”, “Experiment contribution”, and “Data set contribution” information. The protein and peptide information can also be accessed via the Candida Genome Database via hyperlinks on each protein page. This allows users to peruse identified peptides, protein coverage, post-translational modifications (PTMs), and experiments that identify each protein. Given the value of understanding the PTM landscape in the sequence of each protein, a more detailed explanation of how to interpret and analyze PTM results is provided in the PeptideAtlas of this important pathogen. Candida albicans PeptideAtlas web page: https://db.systemsbiology.net/sbeams/cgi/PeptideAtlas/buildDetails?atlas_build_id=578.
PB ACS Publications
SN 1535-3893
YR 2025
FD 2025
LK https://hdl.handle.net/20.500.14352/120815
UL https://hdl.handle.net/20.500.14352/120815
LA eng
NO Gomez-Artiguez L, De La Cámara-Fuentes S, Sun Z, Hernáez ML, Borrajo A, Pitarch A, et al. Candida albicans : A Comprehensive View of the Proteome. J Proteome Res 2025;24:1636–48. https://doi.org/10.1021/acs.jproteome.4c01020
NO This work was granted by PID2021-124062NB-I00 (CG) funded by Spanish Ministry of Science and Innovation/State Research Agency 10.13039/501100011033, the National Institutes of Health grants R01 GM087221 (EWD, RLM), U19 AG023122 (RLM), S10 OD026936 (RLM), and the National Science Foundation grants DBI-1933311 (EWD) and MRI-1920268 (RLM). L. Gomez-Artiguez was supported by a contract funded by grant CT19/23-INVM-70 from the European Union- NextGenerationEU, as part of Investigo program in the frame of “Recovery, Transformation and Resilience Plan” cofunded by the Ministry of Labor and Social Economy and the National Public Employment Service. S. de la Cámara-Fuentes was supported by PTA2022-022414-I from the Spanish Ministry of Science and Innovation and the State Research Agency, along with REACT-UE ANTICIPA-CM from the Community of Madrid.
NO Agencia Estatal de Investigación (España)
NO European Commission
NO Ministerio de Trabajo y Economía Social (España)
NO Ministerio de Ciencia e Innovación (España)
NO Comunidad de Madrid
NO National Science Foundation
NO National Institutes of Health
DS Docta Complutense
RD 20 mar 2026