RT Journal Article
T1 Toxicity of the Anti-ribosomal Lectin Ebulin f in Lungs and Intestines in Elderly Mice
A1 Garrosa, Manuel
A1 Jimenez López, Pilar
A1 Tejero, Jesús
A1 Cabrero, Patricia
A1 Córdoba Díaz, Damián
A1 Quinto, Emiliano
A1 Gayoso, Manuel
A1 Girbés Juan, Tomás
AB All parts of dwarf elder (Sambucus ebulus L.) studied so far contain a ribosome-inactivating protein with lectin activity (ribosome-inactivating lectin; RIL), known as ebulin. Green fruits contain ebulin f, the toxicity of which has been studied in six-week-old mice, where it was found that the intestines were primary targets for it when administered intraperitoneally (i.p.). We performed experiments to assess whether ebulin f administration to six- and 12-month-old mice would trigger higher toxicity than that displayed in six-week-old mice. In the present report, we present evidence indicating that the toxicological effects of ebulin f after its i.p. administration to elderly mice are exerted on the lungs and intestines by an increased rate of apoptosis. We hypothesize that the ebulin f apoptosis-promoting action together with the age-dependent high rate of apoptosis result in an increase in the lectin’s toxicity, leading to a higher lethality level.
PB MDPI
SN 2072-6651
YR 2015
FD 2015-02-02
LK https://hdl.handle.net/20.500.14352/23928
UL https://hdl.handle.net/20.500.14352/23928
LA eng
NO Comunidad de Madrid/Universidad Complutense de Madrid
DS Docta Complutense
RD 18 abr 2025