RT Journal Article
T1 BMP Signalling at the Crossroad of Liver Fibrosis and Regeneration
A1 Herrera González, Blanca
A1 Addante, Annalisa
A1 Sánchez Muñoz, Aránzazu
AB Bone Morphogenetic Proteins (BMPs) belong to the Transforming Growth Factor-β (TGF-β) family. Initially identified due to their ability to induce bone formation, they are now known to have multiple functions in a variety of tissues, being critical not only during development for tissue morphogenesis and organogenesis but also during adult tissue homeostasis. This review focus on the liver as a target tissue for BMPs actions, devoting most efforts to summarize our knowledge on their recently recognized and/or emerging roles on regulation of the liver regenerative response to various insults, either acute or chronic and their effects on development and progression of liver fibrosis in different pathological conditions. In an attempt to provide the basis for guiding research efforts in this field both the more solid and more controversial areas of research were highlighted.
PB MDPI
SN 1422-0067
YR 2017
FD 2017-12-23
LK https://hdl.handle.net/20.500.14352/19210
UL https://hdl.handle.net/20.500.14352/19210
LA eng
NO Unión Europea. FP7
NO Ministerio de Economía y Competitividad (MINECO)
DS Docta Complutense
RD 28 abr 2024