RT Journal Article
T1 Thermoresponsive Polymeric Nanolenses Magnify the Thermal Sensitivity of Single Upconverting Nanoparticles
A1 Lu, Dasheng
A1 Rubio Retama, Jorge
A1 Marin, Riccardo
A1 Marqués Ponce, Manuel Ignacio
A1 Gómez Calderón, Óscar
A1 Melle Hernández, Sonia
A1 Haro González, Patricia
A1 Jaque García, Daniel
AB Lanthanide-based upconverting nanoparticles (UCNPs) are trustworthy workhorses in luminescent nanothermometry. The use of UCNPs-based nanothermometers has enabled the determination of the thermal properties of cell membranes and monitoring of in vivo thermal therapies in real time. However, UCNPs boast low thermal sensitivity and brightness, which, along with the difficulty in controlling individual UCNP remotely, make them less than ideal nanothermometers at the single-particle level. In this work, it is shown how these problems can be elegantly solved using a thermoresponsive polymeric coating. Upon decorating the surface of NaYF4 :Er3+ ,Yb3+ UCNPs with poly(N-isopropylacrylamide) (PNIPAM), a >10-fold enhancement in optical forces is observed, allowing stable trapping and manipulation of a single UCNP in the physiological temperature range (20-45 °C). This optical force improvement is accompanied by a significant enhancement of the thermal sensitivity- a maximum value of 8% °C+1 at 32 °C induced by the collapse of PNIPAM. Numerical simulations reveal that the enhancement in thermal sensitivity mainly stems from the high-refractive-index polymeric coating that behaves as a nanolens of high numerical aperture. The results in this work demonstrate how UCNP nanothermometers can be further improved by an adequate surface decoration and open a new avenue toward highly sensitive single-particle nanothermometry.
PB Wiley
SN 1613-6810
YR 2022
FD 2022-07-30
LK https://hdl.handle.net/20.500.14352/73319
UL https://hdl.handle.net/20.500.14352/73319
LA eng
NO © 2022 The Authors. Small published by Wiley-VCH GmbH
NO Ministerio de Ciencia e Innovación de España
NO Comunidad de Madrid (España)
NO Carl Tiggers Foundation (Estocolmo)
NO Universidad Autónoma de Madrid (España)
NO China Scholarship Council
DS Docta Complutense
RD 17 ago 2024