RT Journal Article
T1 A versatile drug delivery system targeting senescent cells
A1 Muñoz Espín, Daniel
A1 Ucero Herrería, Álvaro Conrado
A1 Serrano, Manuel
AB Senescent cells accumulate in multiple aging‐associated diseases, and eliminating these cells has recently emerged as a promising therapeutic approach. Here, we take advantage of the high lysosomal β‐galactosidase activity of senescent cells to design a drug delivery system based on the encapsulation of drugs with galacto‐oligosaccharides. We show that gal‐encapsulated fluorophores are preferentially released within senescent cells in mice. In a model of chemotherapy‐induced senescence, gal‐encapsulated cytotoxic drugs target senescent tumor cells and improve tumor xenograft regression in combination with palbociclib. Moreover, in a model of pulmonary fibrosis in mice, gal‐encapsulated cytotoxics target senescent cells, reducing collagen deposition and restoring pulmonary function. Finally, gal‐encapsulation reduces the toxic side effects of the cytotoxic drugs. Drug delivery into senescent cells opens new diagnostic and therapeutic applications for senescence‐associated disorders.
PB Springer Nature
SN 1757-4684
YR 2018
FD 2018-07-16
LK https://hdl.handle.net/20.500.14352/133194
UL https://hdl.handle.net/20.500.14352/133194
LA eng
NO Muñoz-Espín D, Rovira M, Galiana I, Giménez C, Lozano-Torres B, Paez-Ribes M, Llanos S, Chaib S, Muñoz-Martín M, Ucero AC, Garaulet G, Mulero F, Dann SG, VanArsdale T, Shields DJ, Bernardos A, Murguía JR, Martínez-Máñez R, Serrano M. A versatile drug delivery system targeting senescent cells. EMBO Molecular Medicine. 2018;10(9):e9355. doi:10.15252/emmm.201809355. PMID: 30158295.
DS Docta Complutense
RD 19 mar 2026