RT Journal Article
T1 Exploring trained immunity to complement vaccination against Streptococcus suis in swine
A1 Sánchez Morales, Lidia
A1 Pérez Sancho, Marta
A1 García-Seco Romero, María Teresa
A1 Balseiro, Ana
A1 Pérez-Domingo, Andrea
A1 Buendía, Aránzazu
A1 Díez Guerrier, Alberto Antoine
A1 de Garnica García, María García
A1 Mareque, Patricia
A1 de los Ángeles Risalde, María
A1 Gortázar, Christian
A1 Domínguez, Mercedes
A1 Domínguez Rodríguez, Lucas José
AB Streptococcus suis is a major pathogen in swine, causing septicemia, meningitis, and arthritis. Effective control is complicated by the presence of multiple serotypes, genetic heterogeneity, and interference of maternal antibodies with vaccine efficacy. Moreover, the emergence of antibiotic-resistant strains poses additional challenges. Trained immunity, a process of innate immune memory induced by certain stimuli, has been proposed as a novel approach to enhance host defense mechanisms. This study aimed to evaluate whether a mycobacterial-derived immunomodulator (dpB) administered with a specific S. suis vaccine could improve protection in pigs. Thirty-two weaned pigs were allocated into four groups: vaccine alone, vaccine and live dpB, vaccine and inactivated dpB, and non-immunized controls. After two immunizations, animals were challenged with a S. suis serotype 2 strain. Immune responses were assessed through ex vivo blood stimulation, cytokine measurement and phagocytosis assays. The group receiving vaccine and inactivated dpB presented a better response, including reduced bacterial loads in tissues, less severe lung lesions and elevated pre-challenge cytokine levels. Clinically, these animals showed milder symptoms and lower bacterial dissemination post-challenge. While trained immunity remains a relatively new concept in veterinary immunology, these results suggest that inactivated dpB, when combined with specific vaccination, could serve as an effective complementary strategy to improve protection against S. suis. Further research is needed to elucidate the underlying mechanisms and to establish its potential role in comprehensive disease prevention programs
PB Elsevier
SN 0145-305X
YR 2025
FD 2025
LK https://hdl.handle.net/20.500.14352/125481
UL https://hdl.handle.net/20.500.14352/125481
LA eng
NO Sánchez-Morales, L., Pérez-Sancho, M., García-Seco, T., Balseiro, A., Pérez-Domingo, A., Buendía, A., Diez-Guerrier, A., de Garnica García, M. G., Mareque, P., de Los Ángeles Risalde, M., Gortázar, C., Domínguez, M., & Domínguez, L. (2025). Exploring trained immunity to complement vaccination against Streptococcus suis in swine. Developmental and comparative immunology, 105498. Advance online publication. https://doi.org/10.1016/j.dci.2025.105498
NO Credit authorship contribution: statement Lidia Sanchez-Morales: ´ Methodology, Investigation. Marta Perez- ´ Sancho: Methodology, Investigation, Funding acquisition. Teresa García-Seco: Methodology, Investigation, Formal analysis. Ana Balseiro: Methodology, Investigation. Andrea Perez-Domingo: ´ Methodology, Investigation. Aranzazu ´ Buendía: Methodology, Investigation. Alberto Diez-Guerrier: Methodology, Investigation. María García de Garnica García: Methodology, Investigation. Patricia Mareque: Methodology, Investigation. María de los Angeles ´ Risalde: Methodology, Investigation. Christian Gortazar: ´ Supervision, Conceptualization. Mercedes Domínguez: Supervision, Conceptualization. Lucas Domínguez: Supervision, Funding acquisition, Conceptualization.
NO Ministerio de Ciencia, Innovación y Universidades (España)
NO Universidad Complutense de Madrid y Banco Santander
DS Docta Complutense
RD 1 abr 2026