RT Journal Article
T1 UVA-degradable Collagenase Nanocapsules as a potential treatment for fibrotic disease.
A1 Moreno Zafra, Víctor Manuel
A1 Meroño, Carolina
A1 Baeza, Alejandro
A1 Usategui Corral, Alicia
A1 Ortiz Romero, Pablo Luis
A1 Pablos Álvarez, José Luis
A1 Vallet Regí, María Dulce Nombre
AB Peyronie and Dupuytren are pathologies characterized by the appearance of localized fibrotic lesions in an organ. These disorders originate from an excessive production of collagen in the tissue provoking dysfunction and functional limitations to the patients. Local administration of collagenase is the most used treatment for these fibrotic-type diseases, but a high lability of the enzyme limits its therapeutic efficacy. Herein, we present a novel methodology for the preparation of collagenase nanocapsules without affecting its enzymatic activity and capable of releasing the enzyme in response to an ultraviolet A (UVA) light stimulus. Polymeric coating around collagenase was formed by free-radical polymerization of acrylamide-type monomers. Their degradation capacity under UVA irradiation was provided by incorporating a novel photocleavable acrylamide-type crosslinker within the polymeric framework. This property allowed collagenase release to be triggered in a controlled manner by employing an easily focused stimulus. Additionally, UVA irradiation presents considerable benefits by itself due to its capacity to induce collagenase production in situ. An expected synergistic effect of collagenase nanocapsules in conjunction with UVA effect may present a promising treatment for these fibrotic diseases.
PB MDPI
SN 1999-4923
YR 2021
FD 2021-04-06
LK https://hdl.handle.net/20.500.14352/7961
UL https://hdl.handle.net/20.500.14352/7961
LA eng
NO Moreno Zafra, V. M., Meroño, C., Baeza, A. et al. «UVA-Degradable Collagenase Nanocapsules as a Potential Treatment for Fibrotic Diseases». Pharmaceutics, vol. 13, n.o 4, abril de 2021, p. 499. DOI.org (Crossref), https://doi.org/10.3390/pharmaceutics13040499.
NO RESEARCHER ID K-8193-2014  (Alejandro Baeza)ORCID 0000-0002-9042-8865 (Alejandro Baeza)RESEARCHER ID M-3378-2014 (María Vallet Regí)ORCID 0000-0002-6104-4889 (María Vallet Regí)
NO Unión Europea
DS Docta Complutense
RD 10 abr 2025