RT Journal Article
T1 AβPP/PS1 Transgenic Mice Show Sex Differences in the Cerebellum Associated with Aging
A1 Ordóñez Gutiérrez, Lara
A1 Fernandez Perez, Ivan
A1 Herrera, Jose Luis
A1 Anton, Marta
A1 Benito Cuesta, Irene
A1 Wandosell, Francisco
AB Cerebellar pathology has been related to presenilin 1 mutations in certain pedigrees of familial Alzheimer's disease. However, cerebellum tissue has not been intensively analyzed in transgenic models of mutant presenilins. Furthermore, the effect of the sex of the mice was not systematically analyzed, despite the fact that important gender differences in the evolution of the disease in the human population have been described. We analyzed whether the progression of amyloidosis in a double transgenic mouse, AβPP/PS1, is susceptible to aging and differentially affects males and females. The accumulation of amyloid in the cerebellum differentially affects males and females of the AβPP/PS1 transgenic line, which was found to be ten-fold higher in 15-month-old females. Amyloid-β accumulation was more evident in the molecular layer of the cerebellum, but glia reaction was only observed in the granular layer of the older mice. The sex divergence was also observed in other neuronal, survival, and autophagic markers. The cerebellum plays an important role in the evolution of the pathology in this transgenic mouse model. Sex differences could be crucial for a complete understanding of this disease. We propose that the human population could be studied in this way. Sex-specific treatment strategies in human populations could show a differential response to the therapeutic approach.
PB IOS Press
SN 1387-2877
SN 1875-8908
YR 2016
FD 2016-09-06
LK https://hdl.handle.net/20.500.14352/114280
UL https://hdl.handle.net/20.500.14352/114280
LA eng
NO Ordoñez-Gutierrez, L., Fernandez-Perez, I., Herrera, J. L., Anton, M., Benito-Cuesta, I., & Wandosell, F. (2016). Aβpp/ps1 transgenic mice show sex differences in the cerebellum associated with aging. Journal of Alzheimer’s Disease, 54(2), 645-656. https://doi.org/10.3233/JAD-160572
NO CIBERNED
NO Dirección General de Ciencia y Tecnología -DGCYT
NO European Community's Seventh Framework Programme
NO Comunidad de Madrid
DS Docta Complutense
RD 1 abr 2026