RT Journal Article
T1 Maleimide and Cyclooctyne-Based Hexakis-Adducts of Fullerene: Multivalent Scaffolds for Copper-Free Click Chemistry on Fullerenes
A1 Ramos Soriano, Javier
A1 Reina, José J.
A1 Illescas, Beatriz M.
A1 Rojo, Javier
A1 Martín, Nazario
AB The synthesis of multivalent systems based on hexakisadducts of [60]fullerene employing a biocompatible copper-free click chemistry strategy has been accomplished. A symmetric hexakis-adduct of fullerene bearing 12 maleimide units (3) is reported, and it has been employed to carry out the thiol-maleimide Michael addition. To achieve orthogonal click addition, an asymmetric derivative bearing one maleimide and 10 cyclooctynes has been synthesized. The sequential and one-pot transformations of the two clickable groups have been explored, finding the best results in the case of the one-pot experiment. This route has been used to obtain a biocompatible hexakis-adduct appended with two different biomolecules, carbohydrates, and amino acids.
PB ACS
SN 0022-3263 (Print)1520-6904 (Online)
YR 2018
FD 2018-01-09
LK https://hdl.handle.net/20.500.14352/11975
UL https://hdl.handle.net/20.500.14352/11975
LA eng
NO Unión Europea. FP7
NO Ministerio de Economía y Competitividad (MINECO)
NO Comunidad de Madrid
DS Docta Complutense
RD 12 abr 2025