TY - JOUR AU - Morales-Cano, Daniel AU - Barreira, Bianca AU - Pandolfi, Rachele AU - Villa-Valverde, Palmira AU - Izquierdo García, José Luis AU - Esquivel Ruiz, Sergio Antonio AU - Callejo Arranz, María AU - Rodríguez Ramírez De Arellano, Ignacio AU - Cogolludo Torralba, Ángel Luis AU - Ruiz-Cabello Osuna, Jesús AU - Pérez Vizcaíno, Francisco AU - Moreno Gutiérrez, Laura PY - 2023 DO - 10.3389/fphar.2023.1021535 UR - https://hdl.handle.net/20.500.14352/92876 T2 - Front. Pharmacol AB - Background: Despite increasing evidence suggesting that pulmonary arterial hypertension (PAH) is a complex disease involving vasoconstriction, thrombosis, inflammation, metabolic dysregulation and vascular proliferation, all the drugs approved for PAH... LA - eng PB - Frontiers KW - Pulmonary hypertension, KW - Antiproliferative KW - Metabolomics KW - Combination therapy KW - Right ventricle TI - Impact of a TAK-1 inhibitor as a single or as an add-on therapy to riociguat on the metabolic reprograming and pulmonary hypertension in the SUGEN5416/hypoxia rat model TY - journal article VL - 14 ER -