RT Journal Article
T1 Withanolide-Type Steroids from Physalis nicandroides Inhibit HIV Transcription
A1 Taddeo, Vito A.
A1 Núñez, Marvin J.
A1 Beltrán, Manuela
A1 Castillo, Ulises G.
A1 Menjívar, Jenny
A1 Jiménez, Ignacio A.
A1 Alcamí, José
A1 Bedoya Del Olmo, Luis Miguel
A1 Bazzocchi, Isabel L.
AB The aim of the present study is to report the isolation, structural elucidation, and antiviral evaluation of four new withanolide-type steroids, named nicansteroidins A-D (1-4), together with nine related known compounds (5-13) isolated from the aerial parts of Physalis nicandroides. Their structures were established based on an extensive spectroscopic analysis, including 1D and 2D NMR techniques. Outstandingly, nicansteroidins A and B possess an unusual side chain with an exocyclic double bond on the δ-lactone system, whereas nicansteroidins C and D have an uncommon cycloperoxide functionality in ring A as distinct structural motifs. Their biological evaluation as inhibitors of human immunodeficiency virus type 1 replication revealed that two compounds from this series, 7 and 13, displayed strong inhibition of HIV-1 replication with IC50 values lower than 2 μM. Moreover, cellular mechanism experiments showed that the main target of these compounds in the HIV replication cycle is viral transcription. This study is the first report of withanolide-type steroids as HIV inhibitors and provides insight into their potential as candidates for further preclinical studies.
PB ACS Publications
YR 2021
FD 2021-09-22
LK https://hdl.handle.net/20.500.14352/125161
UL https://hdl.handle.net/20.500.14352/125161
LA eng
NO Taddeo VA, Núñez MJ, Beltrán M, Castillo UG, Menjívar J, Jiménez IA, Alcamí J, Bedoya LM, Bazzocchi IL. Withanolide-Type Steroids from Physalis nicandroides Inhibit HIV Transcription. J Nat Prod 2021;84:2717–26. https://doi.org/10.1021/acs.jnatprod.1c00637.
NO Instituto de Salud Carlos III (España)
NO Universidad Complutense de Madrid
DS Docta Complutense
RD 15 abr 2026