RT Journal Article
T1 Lysine-Grafted MCM-41 Silica as An Antibacterial Biomaterial
A1 Villegas, María Fernanda
A1 García Uriostegui, Lorena
A1 Rodríguez, Ofelia
A1 Izquierdo Barba, Isabel
A1 Salinas Sánchez, Antonio Jesús
A1 Toriz, Guillermo
A1 Vallet Regí, María Dulce Nombre
A1 Delgado, Ezequiel
AB Abstract: A facile strategy for zwitterionization of bioceramics based on direct incorporation of L-lysine amino acid via the ε-amino group onto mesoporous MCM-41 materials is proposed. FTIR studies of lysine-grafted MCM-41 (MCM-LYS) showed simultaneously bands at 3080 and 1540 cm−1 and bands at 1625 and 1415 cm−1 corresponding to -NH3+/COO− pairs, demonstrating the incorporation of the amino acid on the material surface keeping its zwitterionic character. Both elemental and thermogravimetric analyses showed that the amount of grafted lysine was 8 wt % based on the bioceramic total weight. Moreover, MCM-LYS material exhibited a reduction of adhesion of S. aureus and E. coli bacteria in 33 and 50%, respectively at physiological pH, as compared with pristine MCM-41. Biofilm studies onto surfaces showed that lysine functionalization elicited a reduction of the area covered by S. aureus biofilm from 42% to only 5% (88%). This research shows a simple and effective approach to chemically modify bioceramics using single amino acids that provide zwitterionic functionality, useful to develop new biomaterials able to resist bacterial adhesion.
PB MDPI
SN 2306-5354; CODEN: BIOEBG
YR 2017
FD 2017
LK https://hdl.handle.net/20.500.14352/18120
UL https://hdl.handle.net/20.500.14352/18120
LA eng
NO Villegas, M. F., García Uriostegui, L., Rodríguez, O. et al. «Lysine-Grafted MCM-41 Silica as an Antibacterial Biomaterial». Bioengineering, vol. 4, n.o 4, septiembre de 2017, p. 80. DOI.org (Crossref), https://doi.org/10.3390/bioengineering4040080.
NO ORCID 0000-0002-6104-4889 (María Vallet Regí)RESEARCHER ID M-3378-2014 (María Vallet Regí)
NO Unión Europea. H2020
NO Ministerio de Economía, Comercio y Empresa (España)
NO Consejo Nacional de Ciencia y Tecnologίa (México) 
DS Docta Complutense
RD 22 abr 2025