RT Journal Article
T1 A History of the Pharmacological Treatment of Bipolar Disorder
A1 López-Muñoz, Francisco
A1 Shen, Winston
A1 D’Ocon, Pilar
A1 Romero Martínez, Manuel Alejandro
A1 Álamo, Cecilio
AB In this paper, the authors review the history of the pharmacological treatment of bipolar disorder, from the first nonspecific sedative agents introduced in the 19th and early 20th century, such as solanaceae alkaloids, bromides and barbiturates, to John Cade’s experiments with lithium and the beginning of the so-called “Psychopharmacological Revolution” in the 1950s. We also describe the clinical studies and development processes, enabling the therapeutic introduction of pharmacological agents currently available for the treatment of bipolar disorder in its different phases and manifestations. Those drugs include lithium salts, valproic acid, carbamazepine, new antiepileptic drugs, basically lamotrigine and atypical antipsychotic agents (olanzapine, risperidone, quetiapine, ziprasidone, aripiprazole, asenapine, cariprazine and lurasidone). Finally, the socio-sanitary implications derived from the clinical introduction of these drugs are also discussed.
PB MDPI
SN 1422-0067
YR 2018
FD 2018-07-23
LK https://hdl.handle.net/20.500.14352/12516
UL https://hdl.handle.net/20.500.14352/12516
LA eng
DS Docta Complutense
RD 8 abr 2025