RT Journal Article
T1 Assessment of circulating concentrations of proinflammatory and anti-inflammatory cytokines and nitric oxide in dogs with brachycephalic airway obstruction syndrome
A1 Rancán, Lisa
A1 Romussi, Stefano
A1 García Fernández, Paloma María
A1 Albertini, Mariangela
A1 Vara Ameigeiras, Elena María
A1 Sánchez De La Muela, María Mercedes
AB Objective—To evaluate plasma concentrations of inflammatory mediators in dogs with brachycephalic airway obstruction syndrome, identify a possible role for these mediators in the syndrome, and investigate the relationship between plasma concentrations of inflammatory mediators and severity of clinical signs.Animals—17 dogs with brachycephalic airway obstruction syndrome and 10 mesocephalic (control) dogs.Procedures—A blood sample was collected once from each dog. Plasma concentrations of interleukin (IL)-1β, tumor necrosis factor (TNF)-α, IL-6, IL-17A, IL-10, and IL-13 were measured with ELISAs. Nitric oxide (NO) concentrations were determined with a Griess test. For analysis, brachycephalic dogs were categorized into groups depending on weight (smal [< 16 kg]) and large [≥ 16 kg]) or on whether they required medical or surgical treatment.Results—Compared with control dog values, plasma concentrations of TNF-α, IL-10, IL-13, and IL-17A were significantly higher in brachycephalic dogs and markedly so for brachycephalic dogs that required surgery; findings for small and large brachycephalic dogs did not differ. A similar pattern of differences between control and brachycephalic dogs was dentified for plasma NO concentration. Plasma IL-1β and IL-6 concentrations in control and brachycephalic dogs did not differ.Conclusions and Clinical Relevance—In brachycephalic dogs, plasma TNF-α, IL-10, IL-13, L-17A, and NO concentrations were higher than values in control dogs and appeared to be associated with disease severity. These variables may be useful as indicators of inflammatory processes associated with brachycephalic airway obstruction syndrome in dogs.
PB American Veterinary Medical Association (AVMA)
SN 0002-9645
YR 2013
FD 2013
LK https://hdl.handle.net/20.500.14352/93141
UL https://hdl.handle.net/20.500.14352/93141
LA eng
NO Rancan, L., Romussi, S., Garcia, P., Albertini, M., Vara, E., & de la Muela, M. S. (2013). Assessment of circulating concentrations of proinflammatory and anti-inflammatory cytokines and nitric oxide in dogs with brachycephalic airway obstruction syndrome. American Journal of Veterinary Research, 74(1), 155-160. Retrieved Jun 12, 2024, from https://doi.org/10.2460/ajvr.74.1.155
DS Docta Complutense
RD 10 abr 2025