TY  - JOUR
AU  - García-Hernández, Alberto
AU  - Pardo, María Del Carmen
AU  - Rizopoulos, Dimitris
AU  - Pérez Pérez, Teresa
PY  - 2020
DO  - 10.1002/pst.2045
UR  - https://hdl.handle.net/20.500.14352/110255
T2  - Pharmaceutical Statistics
AB  - AbstractIn pre-marketing stages of drug development, trialists focus on drug efficacy rather than effectiveness, and observations collected after study drug discontinuation are excluded from the analysis, following the so-called "de jure" estimand. In...
LA  - eng
M2  - 909
PB  - Wiley
KW  - MMRM
KW  - de jure estimand
KW  - hypothetical strategy estimand
KW  - joint modeling
KW  - shared parameter models
TI  - MMRM vs. joint modeling of longitudinal responses and time to study drug discontinuation in clinical trials using a ‘de jure’ estimand
TY  - journal article
VL  - 19
ER  -