RT Journal Article
T1 Efficient and safe internalization of magnetic iron oxide nanoparticles: Two fundamental requirements for biomedical application
A1 Calero Calero, Macarena
A1 Gutiérrez, Lucía
A1 Salas, Gorka
A1 Luengo Morato, Yurena
A1 Lázaro, Ana
A1 Morales, María del Puerto
A1 Miranda, Rodolfo
A1 Villanueva, Ángeles
AB Development of nanosized materials to enhance the image contrast between the normal and  diseased tissue and/or to indicate the status of organ functions or blood flow is essential in nuclear magnetic resonance imaging (MRI). Here we describe a contrast agent based on a new iron oxide design (superparamagnetic iron oxide clusters embedded in antiferromagnetic iron oxide porous nanorods). We show as a proof-of-concept that aqueous colloidal suspensions containing these particles show enhanced-proton relaxivities (i.e., enhanced MRI contrast capabilities). A remarkable feature of this new design is that large scale production is possible since aqueous-based routes are used, and porosity and iron oxide superparamagnetic clusters are directly developed from a single phase. We have also proved with the help of a simple model that the physical basis behind the increase in relaxivities lies on both the increase of dipolar field (interactions within iron oxide clusters) and the decrease of proton-cluster distance (porosity favors the close contact between protons and clusters). Finally, a list of possible steps to follow to enhance capabilities of this contrast agent is also included (partial coating with noble metals to add extra sensing capacity and chemical functionality, to increase the amount of doping while simultaneously carrying out cytotoxicity studies, or to find conditions to further decrease the size of the nanorods and to enhance their stability).
SN 1549-9642
YR 2014
FD 2014
LK https://hdl.handle.net/20.500.14352/95072
UL https://hdl.handle.net/20.500.14352/95072
LA eng
NO Calero, Macarena, et al. «Efficient and Safe Internalization of Magnetic Iron Oxide Nanoparticles: Two Fundamental Requirements for Biomedical Applications». Nanomedicine: Nanotechnology, Biology and Medicine, vol. 10, n.o 4, mayo de 2014, pp. 733-43. https://doi.org/10.1016/j.nano.2013.11.010
NO Ministerio de Economía y Competitividad (España)
NO Comunidad de Madrid
DS Docta Complutense
RD 4 abr 2025