RT Journal Article
T1 MS4A3-HSP27 target pathway reveals potential for haematopoietic disorder treatment in alimentary toxic aleukia
A1 Lu, Q
A1 Guo, P
A1 Wang, X
A1 Ares Lombán, Irma
A1 López Torres, Bernardo
A1 Martínez Larrañaga, María Rosa
A1 Li, T
A1 Zhang, Y
A1 Wang, X
A1 Martínez Caballero, María Aranzazu
A1 Anadón Navarro, Arturo Ramón
AB Alimentary toxic aleukia (ATA) is correlated with consuming grains contaminated by Fusarium species, particularly T-2 toxin, which causes serious hurt to human and animal health, chiefly in disorders of the haematopoietic system. However, the mechanism of haematopoietic dysfunction induced by T-2 toxin and the possible target pathway for the treatment of T-2 toxin-induced haematopoietic disorder of ATA remains unclear. In this study, genomes and proteomics were used for the first time to investigate the key differential genes and proteins that inhibit erythroid differentiation of K562 cells caused by T-2 toxin, and it was found that heat shock protein 27 (HSP27) and membrane-spanning 4-domains, subfamily A, member 3 (MS4A3) may play an important role in erythroid differentiation. Meanwhile, MS4A3 interference can inhibit the occurrence of erythroid differentiation of K562 cells and promote the phosphorylation of HSP27. Moreover, the binding of HSP27 to MS4A3 in natural state can activate the phosphorylation site of HSP27 (Ser-83), while T-2 toxin can abolish the activation of phosphorylation site by inhibiting the expression of MS4A3. These findings for the first time demonstrated that the MS4A3-HSP27 pathway may function an efficient therapeutic target pathway for treating T-2 toxin elicited haematopoietic disorders of ATA.
PB Springer Nature
SN 0742-2091
YR 2023
FD 2023
LK https://hdl.handle.net/20.500.14352/138658
UL https://hdl.handle.net/20.500.14352/138658
LA eng
NO Lu, Q., Guo, P., Wang, X., Ares, I., Lopez-Torres, B., Martínez-Larrañaga, M. R., Li, T., Zhang, Y., Wang, X., Anadón, A., & Martínez, M. A. (2023). MS4A3-HSP27 target pathway reveals potential for haematopoietic disorder treatment in alimentary toxic aleukia. Cell biology and toxicology, 39(1), 201–216. https://doi.org/10.1007/s10565-021-09639-4
NO National Natural Science Foundation of China (NSFC)
NO Fundamental Research Funds for the Central Universities
NO Ministerio de Ciencia, Innovación y Universidades ( España)
DS Docta Complutense
RD 10 nov 2026