RT Journal Article
T1 Genomic and Functional Regulation of TRIB1 Contributes to Prostate Cancer Pathogenesis
A1 Shahrouzi, Parastoo
A1 Astobiza, Ianire
A1 Cortazar, Ana R.
A1 Torrano, Verónica
A1 Macchia, Alice
A1 Flores Landeira, Juana María
A1 Niespolo, Chiara
A1 Mendizabal, Isabel
A1 Caloto, Rubén
A1 Ercilla, Amaia
A1 Camacho, Laura
A1 Arreal, Leire
A1 Bizkarguenaga, Maider
A1 Martínez Chantar, Maria L.
A1 Bustelo, Xose R.
A1 Berra, Edurne
A1 Kiss-Toth, Endre
A1 Velasco Díez, Guillermo
A1 Zabala-Letona, Amaia
A1 Carracedo, Arkaitz
AB Prostate cancer is the most frequent malignancy in European men and the second worldwide. One of the major oncogenic events in this disease includes amplification of the transcription factor cMYC. Amplification of this oncogene in chromosome 8q24 occurs concomitantly with the copy number increase in a subset of neighboring genes and regulatory elements, but their contribution to disease pathogenesis is poorly understood. Here we show that TRIB1 is among the most robustly upregulated coding genes within the 8q24 amplicon in prostate cancer. Moreover, we demonstrate that TRIB1 amplification and overexpression are frequent in this tumor type. Importantly, we find that, parallel to its amplification, TRIB1 transcription is controlled by cMYC. Mouse modeling and functional analysis revealed that aberrant TRIB1 expression is causal to prostate cancer pathogenesis. In sum, we provide unprecedented evidence for the regulation and function of TRIB1 in prostate cancer.
PB MDPI
SN 2072-6694
YR 2020
FD 2020-09-11
LK https://hdl.handle.net/20.500.14352/8016
UL https://hdl.handle.net/20.500.14352/8016
LA eng
NO Unión Europea. Horizonte 2020
DS Docta Complutense
RD 8 abr 2025