RT Journal Article
T1 Immune function parameters as markers of biological age andpredictors of longevity
A1 Martínez de Toda Cabeza, Irene
A1 Maté, Ianire
A1 Vida, Carmen
A1 Cruces, Julia
A1 Fuente del Rey, Mónica de la
AB Chronological age is not a good indicator of how each individual ages and thus how to maintain good health. Due to the long lifespan in humans and the consequent difficulty of carrying out longitudinal studies, finding valid biomarkers of the biological age has been a challenge both for research and clinical studies. The aim was to identify and validate several immune cell function parameters as markers of biological age. Adult, mature, elderly and long‐lived human volunteers were used. The chemotaxis, phagocytosis, natural killer activity and lymphoproliferation in neutrophils and lymphocytes of peripheral blood were analyzed. The same functions were measured in peritoneal immune cells from mice, at the corresponding ages (adult, mature, old and long lived) in a longitudinal study. The results showed that the evolution of these functions was similar in humans and mice, with a decrease in old subjects.   However, the long‐lived individuals maintained values similar to those in adults. In addition, the values of these functions in adult prematurely aging mice were similar to those in chronologically old animals, and they died before their non‐prematurely aging mice counterparts. Thus, the parameters studied are good markers of the rate of aging, allowing the determination of biological age.
PB Aging
SN 1945-4589
YR 2016
FD 2016
LK https://hdl.handle.net/20.500.14352/23352
UL https://hdl.handle.net/20.500.14352/23352
LA eng
NO Universidad Complutense de Madrid
NO Red Temática de Investigación Cooperativa en Envejecimiento y Fragilidad (RETICEF)
NO FIS, ISCIII-FEDER
DS Docta Complutense
RD 7 abr 2025