RT Journal Article
T1 Steroid pathway and oestrone sulphate production in canine inflammatory mammary carcinoma
A1 Sánchez-Archidona, Ana R.
A1 Jiménez Martínez, María de los Ángeles
A1 Pérez Alenza, María De Los Dolores
A1 Silván Granado, Gema
A1 Illera Del Portal, Juan Carlos
A1 Peña Fernández, Laura Luisa
A1 Dunner Boxberger, Helene Susana
AB Spontaneous canine mammary inflammatory carcinoma (IMC) shares epidemiologic, histopathologic and clinical characteristics with the inflammatory breast carcinoma (IBC) disease in humans. We have analysed the steroids levels in serum and in tissue homogenates of IMC, the expression of two of their receptors (androgen and β-estrogen) and of three enzymes included in the steroidogenesis pathway (aromatase (CYP19A1), steroid sulphatase (STS) and estrogen sulfotransferase (EST)) trying to explain the specific accumulation of steroids in IMC tissues generating deposits in the form of lipid droplets whose presence can be attributed to steroids secreted by IMC cells. According to our working hypothesis, oestrone sulphate would be the main component of these lipid droplets. The presence of these steroid deposits would contribute to the intense proliferation and invasive behaviour of IMC and IBC, although their involvement in angiogenesis is yet to be demonstrated.
PB ELSEVIER SCI LTD
SN 0960-0760
YR 2007
FD 2007
LK https://hdl.handle.net/20.500.14352/96321
UL https://hdl.handle.net/20.500.14352/96321
LA eng
NO Sánchez-Archidona, Ana R., et al. «Steroid pathway and oestrone sulphate production in canine inflammatory mammary carcinoma». The Journal of Steroid Biochemistry and Molecular Biology, vol. 104, n.o 3, mayo de 2007, pp. 93-99. ScienceDirect, https://doi.org/10.1016/j.jsbmb.2007.03.014.
NO Ministerio de Educación y Ciencia (España)
DS Docta Complutense
RD 14 jul 2025