RT Journal Article
T1 CB1 and CB2 cannabinoid receptor antagonists prevent minocycline-induced neuroprotection following traumatic brain injury in mice
A1 López Rodríguez, Ana Belén
A1 Siopi, Eleni
A1 Finn, David P.
A1 Marchand-Leroux, Catherine
A1 García Segura, Luis Miguel
A1 Jafarian-Tehrani, Mehrnaz
A1 Viveros, María Paz
AB Traumatic brain injury (TBI) and its consequences represent one of the leading causes of death in young adults. This lesion mediates glial activation and the release of harmful molecules and causes brain edema, axonal injury, and functional impairment. Since glial activation plays a key role in the development of this damage, it seems that controlling it could be beneficial and could lead to neuroprotective effects. Recent studies show that minocycline suppresses microglial activation, reduces the lesion volume, and decreases TBIinduced locomotor hyperactivity up to 3 months. The endocannabinoid system (ECS) plays an important role in reparative mechanisms and inflammation under pathological situations by controlling some mechanisms that are shared with minocycline pathways. We hypothesized that the ECS could be involved in the neuroprotective effects of minocycline. To address this hypothesis, we used a murine TBI model in combination with selective CB1 and CB2 receptor antagonists (AM251 and AM630, respectively). The results provided the first evidence for the involvement of ECS in the neuroprotective action of minocycline on brain edema, neurological impairment, diffuse axonal injury, and microglial activation, since all these effects were prevented by the CB1 and CB2 receptor antagonists.
PB Oxford Open
SN 1047-3211, ESSN: 1460-2199
YR 2015
FD 2015-01
LK https://hdl.handle.net/20.500.14352/35465
UL https://hdl.handle.net/20.500.14352/35465
LA eng
NO Ministerio de Economía y Competitividad (MINECO)
NO Universidad Complutense de Madrid/Banco de Santander
NO Delegación del Gobierno para el Plan Nacional sobre Drogas (España)
NO Instituto de Salud Carlos III, Redes temáticas de Investigación Cooperativa en salud, Red de Trastornos Adictivos
NO Fondation des Gueules cassées (Paris, France)
DS Docta Complutense
RD 12 abr 2025