RT Journal Article
T1 Sex Differences in Hospital-Acquired Pneumonia among Patients with Type 2 Diabetes Mellitus Patients: Retrospective Cohort Study using Hospital Discharge Data in Spain (2016–2019)
A1 López De Andrés, Ana Isabel
A1 López Herranz, Marta
A1 Hernández Barrera, Valentín
A1 Miguel Díez, Javier De
A1 Miguel Yanes, José María De
A1 Carabantes Alarcón, David
A1 Albaladejo Vicente, Romana
A1 Villanueva Orbaiz, M. Rosa Rita
A1 Jiménez García, Rodrigo
AB Background: To analyze the incidence, clinical characteristics, use of procedures, and in-hospital outcomes in patients who developed pneumonia during their hospital admission according to sex and to the presence of type 2 diabetes mellitus (T2DM). (2) Methods: Retrospective cohort study using data from the Spanish National Hospital Discharge Database. Hospital-acquired pneumonia (HAP) was classed as non-ventilator HAP and ventilator-associated pneumonia (VAP). Separate analyses were performed for men and women with and without T2DM. Population subgroups were compared using propensity score matching. (3) Results: HAP was identified in 38,814 patients (24.07% with T2DM). The adjusted incidence of HAP was higher in patients with T2DM (both sexes) (IRR 1.28; 95% CI 1.25–1.31). The incidence of HAP was higher in men with T2DM than in women with T2DM (adjusted-IR 1.47; 95% CI 1.41–1.53). The incidence of HAP among T2DM patients increased over time. In-hospital mortality (IHM) was around 28% irrespective of T2DM status and sex. After adjusting for confounders and sex, VAP was associated to higher IHM among patients with T2DM (OR 2.09; 95% CI 1.7–2.57). (4) Conclusions: T2DM is associated with a higher risk of HAP, whose incidence increased over time. Men with T2DM have an almost 50% higher risk of HAP than women with T2DM. The probability of dying in the hospital was not associated with sex or T2DM.
PB MDPI
SN 1660-4601
YR 2021
FD 2021-11-30
LK https://hdl.handle.net/20.500.14352/5067
UL https://hdl.handle.net/20.500.14352/5067
LA eng
NO López De Andrés, A. I., López Herranz, M., Miguel Díez, J. et al. «Sex Differences in Hospital-Acquired Pneumonia among Patients with Type 2 Diabetes Mellitus Patients: Retrospective Cohort Study Using Hospital Discharge Data in Spain (2016–2019)». International Journal of Environmental Research and Public Health, vol. 18, n.o 23, noviembre de 2021, p. 12645. DOI.org (Crossref), https://doi.org/10.3390/ijerph182312645.
NO This study is a part of the research funded by the FIS (Fondo de Investigaciones Sanitarias—Health Research Fund, Instituto de Salud Carlos III) and co-financed by the European Union through the Fondo Europeo de Desarrollo Regional (FEDER, “Una manera de hacer Europa”): grant no. PI20/00118.
NO Unión Europea
NO Instituto de Salud Carlos III
DS Docta Complutense
RD 9 abr 2025