RT Journal Article
T1 Temperature modulates systemic and central actions of thyroid hormones on BAT thermogenesis
A1 Rial-Pensado, Eva
A1 Rivas Limeres, Verónica
A1 Grijota Martínez, María Carmen
A1 Rodríguez Díaz, Amanda
A1 Capelli, Valentina
A1 Barca Mayo, Olga
A1 Nogueiras, Rubén
A1 Mittag, Jens
A1 Diéguez, Carlos
A1 López, Miguel
A2 Rahmouni, Kamal
AB Thyroid hormones (THs) play a major role regulating energy balance and brown adipose tissue (BAT) thermogenesis, as well as body temperature, as shown in hyperthyroid patients. However, the current landscape of preclinical thyroid hormone models is complex. For example, while rats become catabolic after TH administration, mice gain weight; so, these differences in species need to be analyzed in detail and specially whether temperature could be a factor. Here, we aimed to investigate the effect of environmental temperature on those actions. Rats were subcutaneously treated with L-thyroxine (T4) or stereotaxically within the ventromedial nucleus of the hypothalamus (VMH) with triiodothyronine (T3) and housed at 23°C, 4°C or 30°C; energy balance, BAT thermogenesis and AMP-activated protein kinase (AMPK) in the VMH were analyzed. Our data showed that the effect of both systemic T4 of central T3 on energy balance and BAT thermogenesis was dependent upon environmental temperature. This evidence is of interest in the design of experimental settings highlighting the species-specific metabolic actions of THs, and in understanding its physiological role in the adaptation to temperature.
PB Frontiers
SN 1664-042X
YR 2022
FD 2022
LK https://hdl.handle.net/20.500.14352/92658
UL https://hdl.handle.net/20.500.14352/92658
LA eng
NO Rial-Pensado E, Rivas-Limeres V, Grijota-Martínez C, Rodríguez-Díaz A, Capelli V, Barca-Mayo O, Nogueiras R, Mittag J, Diéguez C and López M (2022), Temperature modulates systemic and central actions of thyroid hormones on BAT thermogenesis. Front. Physiol. 13:1017381. doi: 10.3389/fphys.2022.1017381
NO Ministerio de Ciencia y Universidades (España)
NO Fundación la Caixa
NO European Commission
DS Docta Complutense
RD 5 abr 2025