RT Journal Article
T1 Combined Effect of Genetic Variants on Long-Term Weight Response after Bariatric Surgery
A1 Torrego-Ellacuría, Macarena
A1 Barabash Bustelo, Ana
A1 Matía Martín, María Del Pilar
A1 Sánchez Pernaute, Andrés
A1 Torres García, Antonio José
A1 Calle Pascual, Alfonso Luis
A1 Rubio Herrera, Miguel Ángel
AB The pathophysiology of body weight control involves complex interactions between hormonal, environmental, behavioral and genetic factors. The purpose of this study was to analyze the association between single nucleotide polymorphisms (SNPs) of 13 genes encoding gastrointestinal peptides, their receptors or the proteins involved in their expression, with long-term weight response in a cohort of 375 patients undergoing bariatric surgery (BS). To evaluate weight response, we combined several variables to define specific response phenotypes six years after surgery. The study protocol was registered in ISRCTN (ID80961259). The analysis of the selected SNPs was performed via allelic discrimination using Taqman® probes (Applied Biosystems, Foster City, CA, USA). The genotype association study was performed using the SNPstat program, with comparisons adjusted for sex, age, initial body mass index, type 2 diabetes, hypertension diagnosis and the type of surgery. We identified eight genetic variants associated with the weight response to BS, independently of the presurgery patient profile and the type of surgical technique, from which we calculated the unweighted risk score (RS) for each phenotype. The highest scoring category in each RS was significantly associated with lower weight loss (p = 0.0001) and greater weight regain (p = 0.0012) at the end of the follow-up.
PB MPDI
YR 2023
FD 2023-06-26
LK https://hdl.handle.net/20.500.14352/103522
UL https://hdl.handle.net/20.500.14352/103522
LA eng
NO Torrego-Ellacuría, M.; Barabash, A.; Matía-Martín, P.; Sánchez-Pernaute, A.; Torres, A.J.; Calle-Pascual, A.L.; Rubio-Herrera, M.A. Combined Effect of Genetic Variants on Long-Term Weight Response after Bariatric Surgery. J. Clin. Med. 2023, 12, 4288. https://doi.org/10.3390/jcm12134288
NO Fundación Mutua Madrileña
NO Fundación Estudios Metabólicos
DS Docta Complutense
RD 6 oct 2024