RT Journal Article
T1 Microwave-Assisted, Solvent-Free Synthesis of Several Quinazoline Alkaloid Frameworks
A1 Cledera, Pilar
A1 Sánchez Cebrián, Juan Domingo
A1 Caballero, Esmeralda
A1 Yates, Tamara
A1 Ramírez, Elena G.
A1 Avendaño López, María Carmen
A1 Ramos García, María Teresa
A1 Carlos Menéndez, 
A1 Menéndez Ramos, José Carlos
AB Microwave irradiation leads to a considerable improvement of the cyclocondensation between anthranilic acid and lactim ethers derived from piperazine-2,5-diones in terms of reaction times, yields, and stereocenter integrity. This reaction has been used to prepare some derivatives of the pyrazino[2,1-b]quinazoline-3,6-dione system present in many quinazoline alkaloids. It could also be applied to the synthesis of compounds containing the complete hexacyclic ring system of the anti-MDR natural product N-acetyl¬ardeemin, and other comprising the pentacyclic framework of circumdatin E. The microwave-assisted reaction was also much better than the thermal one when applied to a bis-lactim ether, leading to the corresponding pentacyclic pyrazino[2,1-b:5,4-b′]diquinazoline-8,16-dione in excellent yield.
YR 2007
FD 2007
LK https://hdl.handle.net/20.500.14352/133517
UL https://hdl.handle.net/20.500.14352/133517
LA eng
NO Cledera, Pilar, et al. «Microwave-Assisted, Solvent-Free Synthesis of Several Quinazoline Alkaloid Frameworks». Synthesis, vol. 2007, n.o 21, noviembre de 2007, pp. 3390-98. DOI.org (Crossref), https://doi.org/10.1055/s-2007-990818.
DS Docta Complutense
RD 16 mar 2026