RT Journal Article
T1 A fluorescent styrylquinoline with combined therapeutic and diagnostic activities against alzheimer’s and prion diseases
A1 Staderini, Matteo
A1 Aulić, Suzana
A1 Bartolini, Manuela
A1 Tran, Hoang Ngoc Ai
A1 González-Ruiz, Víctor
A1 Pérez, Daniel I.
A1 Martínez Gil, Ana
A1 Andrisano, Vincenza
A1 Legname, Giuseppe
A1 Menéndez Ramos, José Carlos
A1 Bolognesi, Maria Laura
A1 Cabezas Baudot, Nieves
A1 Martín Carmona, María Antonia
AB (E)-6-Methyl-4′-amino-2-styrylquinoline (3) is a small molecule with the proper features to potentially diagnose, deliver therapy and monitor response to therapy in protein misfolding diseases. These features include compound fluorescent emission in the NIR region and its ability to interact with both Aβ and prion fibrils, staining them with high selectivity. Styrylquinoline 3 also inhibits Aβ self-aggregation in vitro and prion replication in the submicromolar range in a cellular context. Furthermore, it is not toxic and is able to cross the blood brain barrier in vitro (PAMPA test).
PB ACS publications
SN 1948-5875
YR 2013
FD 2013-01-03
LK https://hdl.handle.net/20.500.14352/99813
UL https://hdl.handle.net/20.500.14352/99813
LA eng
NO Staderini M, Aulić S, Bartolini M, Tran HNA, González-Ruiz V, Pérez DI, et al. A Fluorescent Styrylquinoline with Combined Therapeutic and Diagnostic Activities against Alzheimer’s and Prion Diseases. ACS Med Chem Lett 2013;4:225–9. https://doi.org/10.1021/ml300360
NO Ministerio de Ciencia, Innovación y Universidades (España)
NO Universidad Complutense de Madrid
NO Ministero dell ́ ’Istruzione, dell’Università e della Ricerca (Italia)
NO Consejo Superior de Investigaciones Científicas
DS Docta Complutense
RD 21 jul 2024