RT Journal Article
T1 Complement as a diagnostic tool in immunopathology
A1 López Lera, Alberto
A1 Corvillo, Fernando
A1 Nozal, Pilar
A1 Regueiro González-Barros, José Ramón
A1 Sánchez Corral, Pilar
A1 López Trascasa, Margarita
AB The complement system is a complex and autoregulated multistep cascade at the interface of innate and adaptive immunity. It is activated by immune complexes or apoptotic cells (classical pathway), pathogen-associated glycoproteins (lectin pathway) or a variety of molecular and cellular surfaces (alternative pathway). Upon activation, complement triggers the generation of proteolytic fragments that allow the elimination of the activating surface by enhancing inflammation, opsonization, phagocytosis, and cellular lysis. Moreover, complement efficiently discriminates self from non-self surfaces by means of soluble and membrane-bound complement regulators which are critical for innate self-tolerance. Complement deficiency or dysfunction disturb complement homeostasis and give rise to diseases as diverse as bacterial infections, autoimmunity, or renal and neurological disorders. Research on complement-targeted therapies is an expanding field that has already improved the prognosis of severe diseases such as atypical Haemolytic Uremic syndrome or Paroxysmal Nocturnal Haemoglobinuria. Therefore, complement analysis and monitoring provides valuable information with deep implications for diagnosis and therapy. In addition to its important role as an extracellular defense system, it has now become evident that complement is also present intracellularly, and its activation has profound implications for leukocyte survival and function. In this review, we summarize the essential, up-to-date information on the use of complement as a diagnostic and therapeutic tool in the clinics.
PB Elsevier
SN 1084-9521
YR 2018
FD 2018-06-12
LK https://hdl.handle.net/20.500.14352/106737
UL https://hdl.handle.net/20.500.14352/106737
LA eng
NO López-Lera A, Corvillo F, Nozal P, Regueiro JR, Sánchez-Corral P, López-Trascasa M. Complement as a diagnostic tool in immunopathology. Semin Cell Dev Biol. 2019 Jan;85:86-97. doi: 10.1016/j.semcdb.2017.12.017. Epub 2018 Jan 12. PMID: 29292221.
NO Instituto de Salud Carlos III
NO Fondos FEDER
NO CIBERER
NO Fundación SENEFRO
DS Docta Complutense
RD 7 abr 2025