RT Journal Article
T1 HLA in North Colombia Chimila Amerindians
A1 Arnaiz Villena, Antonio
A1 Palacio Grüber, Jose
A1 Juárez Martín-Delgado, Ignacio
A1 Hernández, Ennio
A1 Muñiz, Ester
A1 Bayona, Brayan
A1 Campos, Cristina
A1 Nieto, Jorge
A1 Martín Villa, José Manuel
A1 Silvera, Carlos
AB HLA-A,-B,-C,-DRB1 and -DQB1 alleles have been studied in Chimila Amerindians from Sabana de San Angel (North Colombian Coast) by using high resolution molecular typing. A frequent extended haplotype was found:HLA-A*24:02-B*51:10-C*15:02-BRB1*04:07-DQB1*03:02 (28.7%) which has also been described in Amerinndian Mayos Mexican population (Mexico, California Gulf, Pacific Ocean). Other haplotypes had already been found in Amerindians from Mexico (Pacific and Atlantic Coast), Peru (highlands and Amazon Basin), Bolivia and North USA. A geographic pattern according to HLA allele or haplotype frequencies is lacking in Amerindians, as already known. Also, five new extended haplotypes were found in Chimila Amerindians. Their HLA-A*24:02 high frequencies characteristic is shared with aboriginal populations of Taiwan; also, HLA-C*01:02 high frequencies are found in New Zealand Maoris, New Caledonians and Kimberly Aborigines from Australia. Finally, this study may show a model of evolutionary factors acting and rising one HLA allele frequency (-A*24:02), but not in others that belong to the same or different HLA loci.
PB Elsevier
SN 0198-8859
YR 2018
FD 2018
LK https://hdl.handle.net/20.500.14352/92521
UL https://hdl.handle.net/20.500.14352/92521
LA eng
NO Arnaiz-Villena A, Palacio-Grüber J, Juarez I, Hernández E, Muñiz E, Bayona B, Campos C, Nieto J, Martin-Villa M, Silvera C. HLA in North Colombia Chimila Amerindians. Hum Immunol. 2018 Apr;79(4):189-190. doi: 10.1016/j.humimm.2018.02.004
NO European Commission 
NO Ministerio de Economía, Comercio y Empresa (España)
DS Docta Complutense
RD 24 abr 2025