RT Journal Article
T1 Substrates of the MAPK Slt2: Shaping Yeast Cell Integrity
A1 González Rubio, Gema
A1 Sastre Vergara, Lucía
A1 Molina, María
A1 Martín Brieva, Humberto
A1 Fernández-Acero Bascones, Teresa
AB The cell wall integrity (CWI) MAPK pathway of budding yeast Saccharomyces cerevisiae is specialized in responding to cell wall damage, but ongoing research shows that it participates in many other stressful conditions, suggesting that it has functional diversity. The output of this pathway is mainly driven by the activity of the MAPK Slt2, which regulates important processes for yeast physiology such as fine-tuning of signaling through the CWI and other pathways, transcriptional activation in response to cell wall damage, cell cycle, or determination of the fate of some organelles. To this end, Slt2 precisely phosphorylates protein substrates, modulating their activity, stability, protein interaction, and subcellular localization. Here, after recapitulating the methods that have been employed in the discovery of proteins phosphorylated by Slt2, we review the bona fide substrates of this MAPK and the growing set of candidates still to be confirmed. In the context of the complexity of MAPK signaling regulation, we discuss how Slt2 determines yeast cell integrity through phosphorylation of these substrates. Increasing data from large-scale analyses and the available methodological approaches pave the road to early identification of new Slt2 substrates and functions.
PB MPDI
SN 2309-608X
YR 2022
FD 2022-04-04
LK https://hdl.handle.net/20.500.14352/71813
UL https://hdl.handle.net/20.500.14352/71813
LA eng
NO González Rubio, G., Sastre Vergara, L., Molina, M. et al. «Substrates of the MAPK Slt2: Shaping Yeast Cell Integrity». Journal of Fungi, vol. 8, n.o 4, abril de 2022, p. 368. DOI.org (Crossref), https://doi.org/10.3390/jof8040368.
NO Ministerio de Ciencia, Innovación y Universidades (España)
NO Comunidad de Madrid/Fondo Europeo de Desarrollo Regional
DS Docta Complutense
RD 5 abr 2025