RT Journal Article
T1 β-Lactam Activity against Penicillin-Resistant Streptococcus pneumoniae Strains Exhibiting Higher Amoxicillin versus Penicillin Minimum Inhibitory Concentration Values: An in vitro Pharmacodynamic Simulation
A1 Sevillano Fernández, David
A1 Aguilar, Lorenzo
A1 Alou Cervera, Luis
A1 Giménez, María José
A1 González Hidalgo, Natalia
A1 Echeverría, Olatz
A1 Torrico, Martha
A1 Valdes, Laura
A1 Coronel, Pilar
A1 Prieto Prieto, José
AB Background: Activity of simulated serum concentrations after oral therapy with 400 mg cefditoren pivoxil b.i.d., 500 mg cefuroxime axetil b.i.d. and 875/125 mg amoxicillin/clavulanic acid b.i.d. and t.i.d. regimens was explored over 24 h against Streptococcus pneumoniae.Methods: Computerized pharmacodynamic simulations were performed against strains with penicillin/amoxicillin/cefuroxime/cefditoren minimum inhibitory concentrations (MICs, µg/ml) and serotypes: strain 1 (0.25/0.12/1/0.12; serotype 6A), strain 2 (2/4/ 2/0.25; serotype 6B), strain 3 (4/16/4/0.5; serotype 14), and strain 4 (4/16/8/1; serotype 14). Results: Bactericidal activity (≧3 log10 reduction) at 12 and 24 h was obtained against all strains with cefditoren, against strains 1 and 2 with cefuroxime and amoxicillin/clavulanic acid t.i.d., but only against strain 1 with amoxicillin/clavulanic acid b.i.d.. Bactericidal activity at 24 h was related to T > MIC of >30% dosing interval, 1.7–2.0 log10 reductions with T > MIC of 20–30%, and <1 log10 reduction or regrowth with T > MIC of 0%. Conclusions: It is difficult to achieve pharmacodynamic coverage and bactericidal activity by physiological concentrations of oral β-lactams against penicillin-resistant pneumococcal strains exhibiting higher amoxicillin versus penicillin MICs. Cefditoren may offer alternatives.
PB Karger
SN 0009-3157
YR 2008
FD 2008
LK https://hdl.handle.net/20.500.14352/107152
UL https://hdl.handle.net/20.500.14352/107152
LA eng
NO Sevillano D, Aguilar L, Alou L, Giménez MJ, González N, Echeverría O, Torrico M, Valdes L, Coronel P, Prieto J. Beta-lactam activity against penicillin-resistant Streptococcus pneumoniae strains exhibiting higher amoxicillin versus penicillin minimum inhibitory concentration values: an in vitro pharmacodynamic simulation. Chemotherapy. 2008;54(2):84-90.
NO Tedec-Meiji SA
NO GlaxoSmithKline SA
DS Docta Complutense
RD 17 abr 2025