RT Journal Article
T1 Serotonin 5-HT6 receptor antagonists for the treatment of cognitive deficiency in Alzheimer's disease
A1 Benhamú Salama, Bellinda
A1 Martín-Fontecha Corrales, María Del Mar
A1 Vázquez Villa, María Del Henar
A1 Pardo, Leonardo
A1 López Rodríguez, María Luz
AB Alzheimer’s disease (AD) is one of the most frequent causes of death and disability worldwide and has a significant clinical and socioeconomic impact. In the search for novel therapeutic strategies, serotonin 5-HT6 receptor (5-HT6R) has been proposed as a promising drug target for cognition enhancement in AD. This manuscript reviews the compelling evidence for the implication of this receptor in learning and memory processes. We have summarized the current status of the medicinal chemistry of 5-HT6R antagonists and the encouraging preclinical findings that demonstrate their significant procognitive behavioral effects in a number of learning paradigms, probably acting through modulation of multiple neurotransmitter systems and signaling pathways. The results of the ongoing clinical trials are eagerly awaited to shed some light on the validation of 5-HT6R antagonists as a new drug class for the treatment of symptomatic cognitive impairment in AD, either as stand-alone therapy or in combination with established agents.
PB ACS Publications
SN 0022-2623
YR 2014
FD 2014-09-11
LK https://hdl.handle.net/20.500.14352/113933
UL https://hdl.handle.net/20.500.14352/113933
LA eng
NO Benhamú, B., Martín-Fontecha, M.,  Vázquez-Villa, H., Pardo, L.,  López-Rodríguez, M. L. Serotonin 5-HT6 Receptor Antagonists for the Treatment of Cognitive Deficiency in Alzheimer’s Disease.  J. Med. Chem. 2014 57 (17), 7160-7181.
NO Ministería de Economía y Competetividad
NO Comunidad de Madrid
DS Docta Complutense
RD 10 abr 2025