RT Book, Section
T1 Fungal ribotoxins: structure, function and evolution
A1 Herrero Galán, Elías
A1 Álvarez García, Elisa
A1 Carreras Sangrà, Nelson
A1 Lacadena García-Gallo, Francisco Javier
A1 Alegre Cebollada, Jorge
A1 Martínez Del Pozo, Álvaro
A1 Oñaderra, Mercedes
A1 Gavilanes, José G.
A2 Proft, Thomas
AB Ribotoxins are a family of fungal extracellular ribonucleases which inactivate ribosomesby specifically cleaving a single phosphodiester bond located at the universallyconserved sarcin/ricin loop of the large rRNA. The subsequent inhibition of proteinbiosynthesis is followed by cell death via apoptosis. Ribotoxins are also able to interactwith membranes containing acid phospholipids, their cytotoxicity being preferentiallydirected towards cells showing altered membrane permeability, e.g. transformed orvirus infected cells. Many features of their cytotoxic action and their ribonucleolyticmechanism have been elucidated by comparison with other extracellular non toxicfungal RNases, best represented by RNase T1. The study of structure-functionrelationships in ribotoxins is of particular interest, since they are postulated as potentialtherapeutic agents against different human pathologies. The production ofhypoallergenic variants with application in several Aspergillus-related allergicsyndromes and the construction of immunotoxins against different carcinomas arepromising examples of such potential therapeutic utilisation.
PB Caister Academic Press
SN 978-1-904455-44-8
YR 2009
FD 2009
LK https://hdl.handle.net/20.500.14352/53872
UL https://hdl.handle.net/20.500.14352/53872
LA eng
NO Ministerio de Educación y Ciencia de España
DS Docta Complutense
RD 20 abr 2025