RT Journal Article
T1 Zinc-doped iron oxide nanoparticles as a proton-activatable agent for dose range verification in proton therapy
A1 España Palomares, Samuel
A1 Espinosa Rodríguez, Andrea
A1 Garcia Diez, Miguel
A1 Martinez Nouvilas, Victor
A1 Sánchez Tembleque Verbo, Víctor
A1 Udías Moinelo, José Manuel
A1 Valladolid Onecha, Víctor
A1 Fraile Prieto, Luis Mario
AB Proton therapy allows the treatment of specific areas and avoids the surrounding tissues. However, this technique has uncertainties in terms of the distal dose fall-off. A promising approach to studying the proton range is the use of nanoparticles as proton-activatable agents that produce detectable signals. For this, we developed an iron oxide nanoparticle doped with Zn (IONP@Zn-cit) with a hydrodynamic size of 10 nm and stability in serum. Cytotoxicity, defined as half of the surveillance, was 100 μg Zn/mL in the U251 cell line. The effect on clonogenic cell death was tested after X-ray irradiation, which suggested a radioprotective effect of these nanoparticles at low concentrations (1–10 μg Zn/mL). To evaluate the production of positron emitters and prompt-gamma signals, IONP@Zn-cit was irradiated with protons, obtaining prompt-gamma signals at the lowest measured concentration (10 mg Zn/mL). Finally, 67Ga-IONP@Zn-cit showed accumulation in the liver and spleen and an accumulation in the tumor tissue of 0.95% ID/g in a mouse model of U251 cells. These results suggest the possibility of using Zn nanoparticles as proton-activatable agents to verify the range by prompt gamma detection and face the challenges of prompt gamma detection in a specific biological situation, opening different avenues to go forward in this field.
PB MDPI
YR 2023
FD 2023-09-29
LK https://hdl.handle.net/20.500.14352/102235
UL https://hdl.handle.net/20.500.14352/102235
LA eng
NO Ibáñez-Moragues, M., Fernández-Barahona, I., Santacruz, R., Oteo, M., Luján-Rodríguez, V. M., Muñoz-Hernando, M., ... & Morcillo, M. Á. (2023). Zinc-Doped Iron Oxide Nanoparticles as a Proton-Activatable Agent for Dose Range Verification in Proton Therapy. Molecules, 28(19), 6874.
NO Artículo firmado por 23 autores
NO Comunidad de Madrid
NO Ministerio de Ciencia e Innovación (España)
NO Agencia Estatal de Investigación (España)
DS Docta Complutense
RD 4 abr 2025