RT Patent
T1 Corticospinal upper motor neurons, methods and compositions for differentiating neural stem cells by modulating CB1 cannabinoid receptor signaling and use thereof
T2 Obere Pyramidenmotoneuronen, Verfahren und Zusammensetzungen zur Unterscheidung neuraler Stammzellen durch Modulation der CB1-Cannabinoidrezeptor-Signalisierung und Verwendungen davon
T2 Neurones moteurs supérieurs cortico-spinaux, procédés et compositions permettant de différencier des cellules souches neurales par modulation de la signalisation des récepteurs cannabinoïdes CB1 et leurs utilisations
A1 Galve Roperh, Ismael
A1 Guzmán Pastor, Manuel
A1 Díaz Alonso, Javier
A1 Aguado Sánchez, Tania
AB The present invention relates to compositions and methods for obtaining a corticospinal upper motor neuron from a neural stem cell comprising the use of a CB1 cannabinoid receptor agonist, or the use of an inhibitor of an endocannabinoid-degrading enzyme, or the modification of a neural stem cell to decrease the expression of an endocannabinoid-degrading enzyme under basal levels or to increase the expression of the CB1 cannabinoid receptor above basal levels. The invention also relates to the corticospinal upper motor neurons obtained and uses thereof.
YR 2012
FD 2012
LK https://hdl.handle.net/20.500.14352/91733
UL https://hdl.handle.net/20.500.14352/91733
LA eng
NO Representante: ABG Patentes, S.L.
DS Docta Complutense
RD 22 abr 2025