RT Journal Article
T1 Aqueous Humor Cytokine Profile in Primary Congenital Glaucoma
A1 Oribio Quinto, Carlos
A1 Burgos Blasco, Barbara
A1 Pérez García, Pilar
A1 Espino Paisán, Laura
A1 Sarriá, Beatriz
A1 Fernández Vigo, José Ignacio
A1 García Feijoo, Julián
A1 Sarriá Ruiz, Beatriz Irene
AB Background: Cytokine profile in patients with primary open-angle glaucoma (POAG) differs from that in healthy controls. Due to the different pathophysiological mechanisms involved in the genesis of primary congenital glaucoma (PCG) and POAG, it is possible that the cytokine profile could also differ. The main objective of this study was to compare the concentrations of cytokines in the aqueous humor of patients with PCG with those of POAG patients and a control group. Methods: A cross-sectional study was conducted. Aqueous humor samples were taken from PCG and POAG patients eligible for glaucoma or cataract surgery and from patients undergoing cataract surgery. Twenty-seven cytokines were analyzed using the Human Cytokine 27-Plex Immunoassay Kit (Bio-Rad Laboratories, Hercules, CA, USA). Results: A total of 107 subjects were included: patients with PCG (n = 19), patients with POAG (n = 54), and a control group (CG) of patients undergoing cataract surgery (n = 34). Most cytokines measured in aqueous humor in PCG presented decreased values compared with POAG and controls. A statistically significant difference was observed in IL-1ra, IL-2, IL-5, IL-7, IL-8, IL-10, IL-12, IL-15, IL-17A, Eotaxin, FGF basic, G-CSF, GM-CSF, IFN-γ, MIP-1α, PDGF-bb, MIP-1β, RANTES, TNF-α, and VEGF. Conclusion: PCG patients have a cytokine profile in aqueous humor different from POAG patients and patients without glaucoma, characterized by lower concentrations of multiple cytokines.
PB MDPI
SN 2077-0383
YR 2023
FD 2023-04-26
LK https://hdl.handle.net/20.500.14352/103567
UL https://hdl.handle.net/20.500.14352/103567
LA eng
NO : Oribio-Quinto, C.; Burgos-Blasco, B.; Pérez-García, P.; Espino-Paisán, L.; Sarriá, B.; Fernández-Vigo, J.I.; García-Feijóo, J. Aqueous Humor Cytokine Profile in Primary Congenital Glaucoma. J. Clin. Med. 2023, 12, 3142. https://doi.org/10.3390/ jcm12093142
DS Docta Complutense
RD 24 abr 2025